Results
| PMID | 22007253 |
| Gene Name | IFNG |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 153 |
| Population details | 156 women undergoing in vitro fertilization (IVF) |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | IL-1, IL-6, IL-18, IFN-gamma, TNF-alpha, IL-12, IL-23, MIP-1?, MIP-1?, MCP-1, RANTES, IL-8, CD47 |
| Other associated phenotypes |
Endometriosis, Infertility, PCOS |
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Clin Dev Immunol. 2012;2012:606459. doi: 10.1155/2012/606459. Epub 2011 Oct 5. Sarapik, Aili| Velthut, Agne| Haller-Kikkatalo, Kadri| Faure, Gilbert C| Bene, Marie-Christine| de Carvalho Bittencourt, Marcelo| Massin, Frederic| Uibo, Raivo| Salumets, Andres Department of Immunology, Institute of General and Molecular Pathology, University of Tartu, Ravila 19, Tartu 50411, Estonia. Cytokines are key modulators of the immune system and also contribute to regulation of the ovarian cycle. In this study, Bender MedSystems FlowCytomix technology was used to analyze follicular cytokines (proinflammatory: IL-1beta, IL-6, IL-18, IFN-gamma, IFN-alpha, TNF-alpha, IL-12, and IL-23;, and anti-inflammatory: G-CSF), chemokines (MIP-1alpha, MIP-1beta, MCP-1, RANTES, and IL-8), and other biomarkers (sAPO-1/Fas, CD44(v6)) in 153 women undergoing in vitro fertilization (IVF). Cytokine origin was studied by mRNA analysis of granulosa cells. Higher follicular MIP-1alpha and CD44(v6) were found to correlate with polycystic ovary syndrome, IL-23, INF-gamma, and TNF-alpha with endometriosis, higher CD44(v6) but lower IL-beta and INF-alpha correlated with tubal factor infertility, and lower levels of IL-18 and CD44(v6) characterized unexplained infertility. IL-12 positively correlated with oocyte fertilization and embryo development, while increased IL-18, IL-8, and MIP-1beta were associated with successful IVF-induced pregnancy. Mesh Terms: Adult| Biomarkers/metabolism| Cytokines/genetics/immunology/*metabolism| Embryonic Development/genetics| Female| *Fertilization in Vitro| Granulosa Cells/immunology/*metabolism/pathology| High-Throughput Screening Assays| Humans| Infertility, Fem |
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